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醫學研究

醫學研究

陳家弘 Chia-Hung Chen

分子生物組 資深助研究員

  • 現職

    新竹馬偕紀念醫院醫學研究科 資深助研究員

     

     

    聯絡方式

    電子信箱: steven.L862@mmh.org.tw

    院內分機: 5522-862

     

  • 主要學歷

    交通大學分子醫學與生物工程研究所 博士 (2009~2013)

    交通大學分子醫學與生物工程研究所 碩士 (2007~2009)

    交通大學生物科技系 學士 (1999~2003)

     

     

    主要經歷

    聯亞藥業股份有限公司 副研究員 (2018~2019)

    康鶴生醫股份有限公司 研究員 (2013~2018)

執行項目或專長

MAJOR SERVICE

針對腫瘤之預防和治療是個人研究的主要方向，而如何達到有效活化生物體的免疫系統來對抗腫瘤便是個人多年來的研究題材，如: 抗癌藥物的運送和腫瘤治療；調控生物體內的免疫力；腫瘤抗原的找尋和疫苗應用等研究主軸。此外，個人也鑽研奈米載體的開發和應用，如微脂體，所以如何將載體應用到腫瘤研究也很有心得。

期刊論文

 

KY Huang, HJ Kao, TH Weng, CH Chen, SL Weng. iDVIP: identification and characterization of viral integrase inhibitory peptides. Briefings in Bioinformatics, 2022

 

 

KY Huang, YJ Tseng, HJ K, CH Chen, HH Yang, SL Weng. Identification of subtypes of anticancer peptides based on sequential features and physicochemical properties. Scientific Reports, 2021.

 

 

WT Lei, KY Huang, JH Jhong, CH Chen, SL Weng. Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants. Scientific Reports, 2021.

 

 

HC Hong, CH Chuang, WC Huang, SL Weng, CH Chen, KH Chang, KW Liao, HD Huang. A panel of eight microRNAs is a good predictive parameter for triple negative breast cancer relapse. Theranostics, 2020.

 

 

PHJ Kao, CH Chen, YW Tsang, CS Lin, HC Chiang, CC Huang, MS Chi, KL Yang, WT Li, SJ Kao, CA Minnaar, KH Chi, YS Wang. Relationship between Energy Dosage and Apoptotic Cell Death by Modulated Electro-Hyperthermia. Scientific Reports, 2020.

 

 

YY Huang, CH Chen, CH Hsu, TY Kuo, CC Liu, Albert TC Liao, CS Lin. Inhibiting Autophagy Potentiates the Antitumor Efficacy of Euphorbia royleana for Canine Mammary Gland Tumors. BMC Veterinary Research, 2020.

 

 

SY Ho, PR Chen, CH Chen*, NM Tsai, YH Lin, CS Lin, CH Chuang, XF Huang, YL Chan, YK Liu, CH Chung, SL Weng, KW Liao. Lipoplex-based targeted gene therapy for the suppression of tumours with VEGFR expression by producing anti-angiogenic molecules. Journal of Nanobiotechnology, 2020.

 

 

YL Lin, CH Chen*, YK Liu, TH Huang, NM Tsai, SC Tzou and KW Liao. Lipo-PEG-PEI complex as an intracellular transporter for protein therapeutics. Int J Nanomedicine. 2019.

 

 

YL Lin, NM Tsai, CH Chen*, YK Liu, CJ Lee, YL Chan, YS Wang, YC Chang, CH Lin, TH Huang, CC Wang, KH Chi and KW Liao. Specific drug delivery efficiently induced human breast tumor regression using a lipoplex by non-covalent association with anti-tumor antibodies. J Nanobiotechnology 2019.

 

 

Hsu WT, Ho SY, Jian TY, Huang HN, Lin YL, CH Chen, Lin TH, Wu MS, Wu CJ, Chan YL, Liao KW. Helicobacter pylori-derived heat shock protein 60 increases the induction of regulatory T-cells associated with persistent infection. Microb Pathog. 2018 Jun;119:152-161.

 

 

Lin YL, CH Chen*, Wu HY, Tsai NM, Jian TY, Chang YC, Lin CH, Wu CH, Hsu FT, Leung TK, Liao KW. Inhibition of breast cancer with transdermal tamoxifen-encapsulated lipoplex. J Nanobiotechnology. 2016.

 

 

CH Chen*, Liu YK, Lin YL, Chuang HY, Hsu WT, Chiu YH, Cheng TL, Liao KW. A rapid and convenient method to enhance transgenic expression in target cells. Prep Biochem Biotechnol. 2012.

 

 

Lin CM, Lin YL, Tsai NM, Wu HY, Ho SY, CH Chen, Liu YK, Chiu YH, Ho LP, Lee RP, Liao KW. Inhibitory effects of chloroform extracts derived from Corbicula fluminea on the release of pro-inflammatory cytokines. J Agric Food Chem. 2012.

 

 

CH Chen*, Lin YL, Liu YK, He PJ, Lin CM, Chiu YH, Wu CJ, Cheng TL, Liu SJ, Liao KW. Liposome-based polymer complex as a novel adjuvant: enhancement of specific antibody production and isotype switch. Int J Nanomedicine. 2012.

 

 

Hwang CH, Lin YL, Liu YK, CH Chen, Wu HY, Chang CC, Chang CY, Chang YK, Chiu YH, Liao KW, Lai YK.7,7''-Dimethoxyagastisflavone-induced apoptotic or autophagic cell death in different cancer cells. Phytother Res. 2012.

 

 

Lin YL, Liu YK, Tsai NM, Hsieh JH, CH Chen, Lin CM, Liao KW. A Lipo-PEG-PEI complex for encapsulating curcumin that enhances its antitumor effects on curcumin-sensitive and curcumin-resistance cells. Nanomedicine. 2012.

 

 

Tseng FJ, Liu YK, Chung YS, Lin YL, CH Chen, Wang WY, Chen YC, Tsai NM, Cheng TL, Pan RY, Hu TM, Lee RP, Liao KW. A fusion protein composed of receptor binding domain of vascular endothelial growth factor-A and constant region fragment of antibody: angiogenesis antagonistic activity. Cytotechnology. 2011.

 

 

Liu YK, Lin YL, CH Chen, Lin CM, Ma KL, Chou FH, Tsai JS, Lin HY, Chen FR, Cheng TL, Chang CC, Liao KW. A unique and potent protein binding nature of liposome containing polyethylenimine and polyethylene glycol: a nondisplaceable property. Biotechnol Bioeng. 2011.

 

 

Tseng FJ, Chen YC, Lin YL, Tsai NM, Lee RP, Chung YS, CH Chen, Liu YK, Huang YS, Hwang CH, Lai YK, Liao KW. A fusion protein with the receptor-binding domain of vascular endothelial growth factor-A (VEGF-A) is an antagonist of angiogenesis in cancer treatment: Simultaneous blocking of VEGF receptor-1 and 2. Cancer Biol Ther. 2010.